Combining Native Mass Spectrometry & Structural Approaches to Drive Early Compound Discovery

• Native mass spectrometry can be utilized as a high-throughput screen which generates a rich and unique dataset during screening campaigns
• Complementary techniques, such as HDX, allow functional hits to be predicted  by monitoring changes in conformational dynamics. These predictions show good  translation into established cellular assays
• The combination of data provides a deeper understanding of structure-activity relationships ahead of initiating medicinal chemistry campaigns

Speakers:

Jonathan Hopper

Founder & Vice President, Platforms

OMass Therapeutics