Rationally Designing Next-Generation ADCs Through Structural Biology, Computational Modelling & Site-Specific Conjugation
2:30 pm - Wednesday 13th January 2027
- Leverage structural modelling to identify optimal antibody conjugation sites, improving ADC stability, payload delivery, and therapeutic performance while reducing empirical design cycles
- Integrate computational modelling and bioinformatics workflows to guide ADC design decisions, accelerate candidate selection, and increase confidence in lead optimisation strategies
- Demonstrate how rational, site-specific ADC engineering translates into improved efficacy and therapeutic index through real-world case studies linking structural insights to preclinical outcomes
