Radoslav Enchev
Group Leader The Francis Crick Institute
Seminars
Wednesday 13th January 2027
Revealing Cryptic Binding Pockets Through High-Throughput Cryo-EM to Unlock Novel Drug Discovery Opportunities
4:30 pm
- Demonstrate how high-throughput cryo-EM captures transient protein conformations and protein-protein interactions in solution to reveal cryptic and previously inaccessible druggable pockets
- Integrate structural visualization with computational design workflows to identify, optimize, and experimentally validate novel molecules targeting rare functional protein states
- Explore how iterative structure generation and validation can create differentiated datasets to power next-generation AI models capable of predicting protein dynamics and accelerating rational drug discovery
